Molecular biology of testicular germ cell tumors

• Published in: Clinical & translational oncology Vol. 18; no. 6; pp. 550 - 556
• Main Authors: Gonzalez-Exposito, R., Merino, M., Aguayo, C.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.06.2016
• Subjects: Humans; Male; Medicine; Medicine & Public Health; Molecular Biology - methods; Molecular Biology - trends; Neoplasms, Germ Cell and Embryonal - genetics; Neoplasms, Germ Cell and Embryonal - therapy; Oncology; Review Article; Testicular Neoplasms - genetics; Testicular Neoplasms - therapy; Testicular germ cell tumors; Molecular biology; Seminoma
• ISSN: 1699-048X; 1699-3055
• DOI: 10.1007/s12094-015-1423-7

Testicular germ cell tumors (TGCTs) are the most common solid tumors in young adult men. They constitute a unique pathology because of their embryonic and germ origin and their special behavior. Genetic predisposition, environmental factors involved in their development and genetic aberrations have been under study in many works throughout the last years trying to explain the susceptibility and the transformation mechanism of TGCTs. Despite the high rate of cure in this type of tumors because its particular sensitivity to cisplatin, there are tumors resistant to chemotherapy for which it is needed to find new therapies. In the present work, it has been carried out a literature review on the most important molecular aspects involved in the onset and development of such tumors, as well as a review of the major developments regarding prognostic factors, new prognostic biomarkers and the possibility of new targeted therapies.