Association of H. pylori infection with gastric carcinoma: a Meta analysis

• Published in: World journal of gastroenterology : WJG Vol. 7; no. 6; pp. 801 - 804
• Main Authors: Xue, F B, Xu, Y Y, Wan, Y, Pan, B R, Ren, J, Fan, D M
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 01.12.2001
• Subjects: Case-Control Studies; Helicobacter Infections - complications; Helicobacter pylori; Humans; Original Research; Stomach Neoplasms - microbiology
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v7.i6.801

To follow the principles of evidence based medicine to reach the integrated results of these studies. Twenty-one papers of case-control studies were selected, including 11 on gastric cancer,7 on precancerous lesion of stomach and 3 on lymphoma of stomach. Meta analysis was used to sum up the odds ratios (OR) of these studies. H. pylori vs gastric cancer (intestinal and diffuse type): the odds ratio from the fixed effect model is 3.0016 (95% CI: 2.4197-3.7234, P<0.001). H. pylori vs precancerous lesion of stomach: a random effect model was used to calculate the summary odds ratio and its value is 2.5635 (95% CI: 1.8477-3.5566, P<0.01). H. pylori vs lymphoma of stomach: though the quantity of literature is too small to make Meta analysis, the data of these 3 studies show that lymphoma of stomach is highly associated with H. pylori infections. Since it had been revealed that H. pylori infection pre-exists in gastric carcinoma and precancerous lesions, the results of Meta analysis present a strong evidence to support the conclusion that H. pylori infection is a risk factor for gastric carcinoma.