Establishment of a new human iPSC cell line (UOMi012-A) from a patient with congenital heart defect who has undergone Fontan procedure

Patients born with complex congenital heart defects, not amenable for surgical repair establishing normal bi-ventricular circulation are palliated with the Fontan Circulation (FC). Here, we report new iPSC line from a patient with tricuspid and pulmonary atresia. The patient underwent series of surg...

Full description

Saved in:
Bibliographic Details
Published inStem cell research Vol. 80; p. 103509
Main Authors Sareen, Niketa, Srivastava, Abhay, Mittal, Ishika, Shah, Ashish H., Dhingra, Sanjiv
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.10.2024
Elsevier
Subjects
Adult
Cell Differentiation
Cell Line
Female
Fontan Procedure
Heart Defects, Congenital - pathology
Heart Defects, Congenital - surgery
Humans
Induced Pluripotent Stem Cells
Online AccessGet full text

Cover

More Information
Summary:Patients born with complex congenital heart defects, not amenable for surgical repair establishing normal bi-ventricular circulation are palliated with the Fontan Circulation (FC). Here, we report new iPSC line from a patient with tricuspid and pulmonary atresia. The patient underwent series of surgeries leading to completion of Fontan circulation at the age of 13yr., and this line was generated when she was 38yr. old. The exact genetic cause of this patient’s congenital heart defect is unknown, and this line will be used for studying molecular and cellular mechanisms responsible for cardiac dysfunction, along with screening for future potential therapeutic avenues.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Report-3
ObjectType-Case Study-4
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103509