Perspective: on the future of fecal microbiota transplantation

Fecal Microbiota Transplantation (FMT) has shown to possess impressive potential benefit for a wide range of clinical indications. Due to its inherent safety issues and efficacy constraints, the use of personalized FMT analogs could be a promising avenue. The development of such analogs will require...

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Published inFrontiers in microbiology Vol. 15; p. 1449133
Main Authors Larsen, Olaf F A, Brummer, Robert J M
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.09.2024
Subjects
analogs
fecal microbiota transplantation
gut microbiota
Microbiology
One Health
personalized
probiotics
analogs
fecal microbiota transplantation
gut microbiota
personalized
One Health
probiotics
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Summary:Fecal Microbiota Transplantation (FMT) has shown to possess impressive potential benefit for a wide range of clinical indications. Due to its inherent safety issues and efficacy constraints, the use of personalized FMT analogs could be a promising avenue. The development of such analogs will require a detailed understanding of their functionality, encompassing not only microbe-host interactions of the microbial taxa that are involved, but also of the ecological dimensions of the analogs and an overview of the gastrointestinal sites where these relevant microbial interactions take place. Moreover, characterization of taxa that have been lost due to diminished exposure to beneficial microbes, as a consequence of Western lifestyle, may lead to creation of future FMT analogs with the capacity to restore functionalities that we have lost.
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Reviewed by: Yiming Meng, China Medical University, China
Edited by: Tetyana Falalyeyeva, Taras Shevchenko National University of Kyiv, Ukraine
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2024.1449133