Visual System Involvement in Patients with Newly Diagnosed Parkinson Disease

• Published in: Radiology Vol. 285; no. 3; pp. 885 - 895
• Main Authors: Arrigo, Alessandro, Calamuneri, Alessandro, Milardi, Demetrio, Mormina, Enricomaria, Rania, Laura, Postorino, Elisa, Marino, Silvia, Di Lorenzo, Giuseppe, Anastasi, Giuseppe Pio, Ghilardi, Maria Felice, Aragona, Pasquale, Quartarone, Angelo, Gaeta, Michele
• Format: Journal Article
• Language: English
• Published: United States 01.12.2017
• Subjects: Aged; Brain - pathology; Diffusion Tensor Imaging - methods; Female; Humans; Male; Middle Aged; Nerve Fibers, Myelinated - pathology; Parkinson Disease - complications; Parkinson Disease - diagnostic imaging; Reproducibility of Results; Sensitivity and Specificity; Vision Disorders - diagnostic imaging; Vision Disorders - etiology; Visual Pathways - diagnostic imaging
• ISSN: 0033-8419; 1527-1315
• DOI: 10.1148/radiol.2017161732

Purpose To assess intracranial visual system changes of newly diagnosed Parkinson disease in drug-naïve patients. Materials and Methods Twenty patients with newly diagnosed Parkinson disease and 20 age-matched control subjects were recruited. Magnetic resonance (MR) imaging (T1-weighted and diffusion-weighted imaging) was performed with a 3-T MR imager. White matter changes were assessed by exploring a white matter diffusion profile by means of diffusion-tensor imaging-based parameters and constrained spherical deconvolution-based connectivity analysis and by means of white matter voxel-based morphometry (VBM). Alterations in occipital gray matter were investigated by means of gray matter VBM. Morphologic analysis of the optic chiasm was based on manual measurement of regions of interest. Statistical testing included analysis of variance, t tests, and permutation tests. Results In the patients with Parkinson disease, significant alterations were found in optic radiation connectivity distribution, with decreased lateral geniculate nucleus V2 density (F, -8.28; P < .05), a significant increase in optic radiation mean diffusivity (F, 7.5; P = .014), and a significant reduction in white matter concentration. VBM analysis also showed a significant reduction in visual cortical volumes (P < .05). Moreover, the chiasmatic area and volume were significantly reduced (P < .05). Conclusion The findings show that visual system alterations can be detected in early stages of Parkinson disease and that the entire intracranial visual system can be involved. RSNA, 2017 Online supplemental material is available for this article.