A ligand for ALK

The receptor tyrosine kinase ALK (anaplastic lymphoma kinase), as its name suggests, is aberrantly activated, mutated, or abundant in multiple cancers. Although widely studied in the context of cancer, the ligand that normally binds to and activates ALK in vertebrates has remained elusive. In this i...

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Bibliographic Details
Published inScience signaling Vol. 8; no. 360; p. fs2
Main Authors Lemke, Greg, Lew, Erin D
Format Journal Article
LanguageEnglish
Published United States 20.01.2015
Subjects
Enzyme Activation - physiology
Heparin - metabolism
Humans
Ligands
Receptor Protein-Tyrosine Kinases - chemistry
Receptor Protein-Tyrosine Kinases - metabolism
Receptor Tyrosine Kinase-like Orphan Receptors - metabolism
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Summary:The receptor tyrosine kinase ALK (anaplastic lymphoma kinase), as its name suggests, is aberrantly activated, mutated, or abundant in multiple cancers. Although widely studied in the context of cancer, the ligand that normally binds to and activates ALK in vertebrates has remained elusive. In this issue of Science Signaling, Murray and colleagues identify heparin as an ALK ligand.
ISSN:1937-9145
DOI:10.1126/scisignal.aaa5566