Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene

• Published in: Stem cell research Vol. 79; p. 103489
• Main Authors: Saegusa, Chika, Mutai, Hideki, Saeki, Tsubasa, Matsuzaki, Saeko, Mizukoshi, Akifumi, Kitajiri, Shin-ichiro, Matsunaga, Tatsuo, Hosoya, Makoto, Okano, Hideyuki, Fujioka, Masato
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.09.2024; Elsevier
• Subjects: Cell Differentiation; Cell Line; Child; Female; Hearing Loss, Sensorineural - genetics; Hearing Loss, Sensorineural - pathology; Humans; Induced Pluripotent Stem Cells - metabolism; Karyotype; Male; Mutation; Trans-Activators - genetics

Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed...