Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene

Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed...

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Published inStem cell research Vol. 79; p. 103489
Main Authors Saegusa, Chika, Mutai, Hideki, Saeki, Tsubasa, Matsuzaki, Saeko, Mizukoshi, Akifumi, Kitajiri, Shin-ichiro, Matsunaga, Tatsuo, Hosoya, Makoto, Okano, Hideyuki, Fujioka, Masato
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.09.2024
Elsevier
Subjects
Cell Differentiation
Cell Line
Child
Female
Hearing Loss, Sensorineural - genetics
Hearing Loss, Sensorineural - pathology
Humans
Induced Pluripotent Stem Cells - metabolism
Karyotype
Male
Mutation
Trans-Activators - genetics
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Summary:Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103489