Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene

Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed...

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Published inStem cell research Vol. 79; p. 103489
Main Authors Saegusa, Chika, Mutai, Hideki, Saeki, Tsubasa, Matsuzaki, Saeko, Mizukoshi, Akifumi, Kitajiri, Shin-ichiro, Matsunaga, Tatsuo, Hosoya, Makoto, Okano, Hideyuki, Fujioka, Masato
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.09.2024
Elsevier
Subjects
Cell Differentiation
Cell Line
Child
Female
Hearing Loss, Sensorineural - genetics
Hearing Loss, Sensorineural - pathology
Humans
Induced Pluripotent Stem Cells - metabolism
Karyotype
Male
Mutation
Trans-Activators - genetics
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Abstract Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
AbstractList Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.
ArticleNumber 103489
Author Saeki, Tsubasa
Mizukoshi, Akifumi
Matsuzaki, Saeko
Kitajiri, Shin-ichiro
Saegusa, Chika
Mutai, Hideki
Hosoya, Makoto
Fujioka, Masato
Matsunaga, Tatsuo
Okano, Hideyuki
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10.1002/stem.1293
10.1016/j.scr.2023.103017
10.1016/j.celrep.2016.12.020
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Snippet Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this...
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SubjectTerms Cell Differentiation
Cell Line
Child
Female
Hearing Loss, Sensorineural - genetics
Hearing Loss, Sensorineural - pathology
Humans
Induced Pluripotent Stem Cells - metabolism
Karyotype
Male
Mutation
Trans-Activators - genetics
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Title Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene
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