Fluorometric determination of sulfadiazine by using molecularly imprinted poly(methyl methacrylate) nanobeads doped with manganese(II)-doped ZnS quantum dots

• Published in: Mikrochimica acta (1966) Vol. 186; no. 9; p. 625
• Main Authors: Gao, Zhikun, Luan, Yu, Lu, Yi, Zhou, Zhiping, Liu, Tianshu, Li, Bolun, Qiu, Zhifeng, Yang, Wenming
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.09.2019
• Subjects: Analytical Chemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Microengineering; Nanochemistry; Nanotechnology; Original Paper; Mn-doped ZnS quantum dots; Sulfadiazine detection; Quenching mechanism; Molecular imprinting polymers; Absorbability
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-019-3721-1

The surface of poly(methyl methacrylate) nanospheres (PMMA-NSs) was molecularly imprinted with sulfadiazine by a surface imprinting method. Simultaneously, Mn(II)-doped ZnS quantum dots were incorporated into the imprinted PMMA-NSs. The morphology of the fluorescent nanoprobe was characterized by transmission electron microscopy which revealed good spheroidal core-shell structure and a homogeneous distribution of the QDs. Following binding of sulfadiazine, fluorescence (best measured at excitation/emission maxima of 335/592 nm) is increasingly quenched. The detection range is 5–40 μmol·L −1 of sulfadiazine, and the detection limit is 0.24 μmol·L −1 . The fluorescence quenching mechanism is discussed, and a photo-induced electron transfer process is shown to account for quenching. The fluorescent probe was applied to the determination of sulfadiazine in spiked tap water with recoveries and RSDs of 96.6–100.2% and 2.7–3.9%, respectively. The detection of sulfadiazine in spiked lake water exhibited the recoveries and RSDs with 99.3–104.8% and 1.8–4.2%, respectively. Graphical abstract Schematic presentation of synthesis of PMMA-Ns, Mn-doped ZnS QDs, MQPs, and the elution diagram of SD from MQPs, and the relative reagents including: sodium dodecyl benzene sulfonate(SDBS), (3-aminopropyl)triethoxysilane(APTES), 3-mercaptopropionic acid (MPA), tetraethylorthosilicate(TEOS)and sulfadiazine(SD), and nanoparticles including: polymer(methyl methacrylate) nanospheres(PMMANs), MIPs@QDs@PMMANs(MQPs) and carbon quantum dots(CQDs).