Transforming Potential of the Anticancer Drug Adriamycin

A Fischer rat embryo cell system in vitro, which had been shown to be highly accurate in identifying chemical carcinogens and to have application in the study of chemicals having anticancer properties, was used to study the anticancer drug adriamycin. At a nontoxic dose adriamycin not only did not p...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 187; no. 4182; pp. 1200 - 1201
Main Authors Price, Paul J., Suk, William A., Skeen, Pamela C., Chirigos, Michael A., Huebner, Robert J.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 28.03.1975
Subjects
Animals
Carcinogens
Cell Line
Cell Transformation, Neoplastic - drug effects
Cholinergic agents
Chromatin
Dosage
Doxorubicin - pharmacology
Embryo, Mammalian
Embryonic cells
Embryos
Gels
Lymphocytes
Methylcholanthrene - pharmacology
Phosphorylation
Rats
Subcultures
Viruses
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Summary:A Fischer rat embryo cell system in vitro, which had been shown to be highly accurate in identifying chemical carcinogens and to have application in the study of chemicals having anticancer properties, was used to study the anticancer drug adriamycin. At a nontoxic dose adriamycin not only did not protect the cells from transformation by the carcinogen 3-methylcholanthrene, but was found in two separate experiments to act on its own as a transforming agent.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1167703