Evaluation of the protective effect of pentoxifylline on carrageenan-induced chronic non-bacterial prostatitis in rats

• Published in: Inflammopharmacology Vol. 25; no. 3; pp. 343 - 350
• Main Authors: Hajighorbani, Mahboobeh, Ahmadi-hamedani, Mahmood, Shahab, Elaheh, Hayati, Farzad, Kafshdoozan, Khatereh, Keramati, Keivan, Amini, Amin Hossein
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2017
• Subjects: Allergology; Animals; Biomedical and Life Sciences; Biomedicine; Carrageenan - pharmacology; Dermatology; Gastroenterology; Immunology; Lipid Peroxidation - drug effects; Male; Original Article; Oxidative Stress - drug effects; Pentoxifylline - pharmacology; Pharmacology/Toxicology; Plant Extracts - pharmacology; Prostatitis - chemically induced; Prostatitis - drug therapy; Prostatitis - metabolism; Protective Agents - pharmacology; Rats; Rats, Wistar; Rheumatology; Secale; Tumor Necrosis Factor-alpha - metabolism; Pentoxifylline; Oxidative stress; Chronic nonbacterial prostatitis; TNF-α
• ISSN: 0925-4692; 1568-5608
• DOI: 10.1007/s10787-017-0335-2

Chronic non-bacterial prostatitis (CNP) is the most common type of prostatitis and oxidative stress (OS) was shown to be highly elevated in prostatitis patients. This study aimed to investigate the protective effect of pentoxifylline (PTX) on CNP induced by carrageenan in rats. Male adult Wistar rats ( n  = 30) were divided into control, CNP and three treatment groups ( n  = 6) including CNP + cernilton and CNP + PTX groups. CNP was induced by single intraprostatic injection of 1% carrageenan (100 µl). Rats in treatment groups received orally cernilton 100 mg/kg and PTX at 50 and 100 mg/kg 1 week after CNP induction for 21 days. Prostatic index (PI), prostatic specific antigen (PSA), tumor-necrosis factor alpha (TNF-α), serum lipid peroxidation (MDA), blood urea nitrogen, creatinine and histopathological changes were compared between groups. There were significant increase of PI, serum levels of PSA, TNF-α and MDA in CNP group at 29 day. In treatment groups, significant reduction in PI, serum levels of PSA, TNF-α, MDA and creatinine was observed especially in rats treated with dose of 50 mg/kg of PTX. In CNP group, histopathological changes of the prostate such as leucocyte infiltration, large involutions and projection into the lumen and reducing the volume of the lumen were observed as well. Whereas PTX, especially at dose of 50 mg/kg, could improve the above-mentioned changes remarkably in CNP treated rats. For the first time, our findings indicated that PTX improved CNP induced by carrageenan in rats.