The Use of Multiparametric Magnetic Resonance Imaging (mpMRI) in the Detection, Evaluation, and Surveillance of Clinically Significant Prostate Cancer (csPCa)

• Published in: Current urology reports Vol. 20; no. 10; p. 60
• Main Authors: Patel, Parth, Wang, Shu, Siddiqui, Mohummad Minhaj
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2019
• Subjects: Biomarkers, Tumor - blood; Humans; Image-Guided Biopsy - methods; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Neoplasm Grading; Neoplasm Staging; Nephrology; Population Surveillance; Prognosis; Prostate Cancer (S Prasad; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Risk Assessment; Section Editor; Topical Collection on Prostate Cancer; Urology; Fusion biopsy; Targeted biopsy; mpMRI; Prostate cancer; Pre-biopsy MRI
• ISSN: 1527-2737; 1534-6285
• DOI: 10.1007/s11934-019-0926-0

Purpose of Review With the long-standing controversy surrounding the use of prostate-specific antigen (PSA) for the detection, evaluation, and surveillance of prostate cancer, there is a need for a minimally invasive technique to identify and risk-stratify these patients. Additionally, in an effort to reduce the number of unnecessary biopsies and identify clinically significant prostate cancer (csPCa), there has been a shift in practice towards the use of multiparametric magnetic resonance imaging (mpMRI) in conjunction with decision-making regarding prostate cancer diagnosis and management. In the current review, we summarize the data regarding the use of mpMRI in the detection, evaluation, and surveillance of csPCa. Recent Findings Recent prospective clinical trials have determined that a pre-biopsy mpMRI may rule out insignificant prostate cancers, thereby reducing the number of patients who require a biopsy. The anatomic information gathered from these pre-biopsy mpMRI performed during MRI fusion biopsy in csPCa increases the accuracy of pathologic staging in terms of Gleason scores. In regard to active surveillance, prospective trials suggest little to no clinical utility for mpMRI and fusion biopsy in the surveillance of prostate cancer despite conflicting findings from retrospective studies. Summary Recent trials suggest that mpMRI can play an important role in the detection and evaluation of csPCa. The ideal role for mpMRI in active surveillance remains limited.