Thermal analysis of arenediazonium tetrafluoroborate salts: Stability and hazardous evaluation

Arenediazonium salts represent an important class of aromatic organic compounds widely used as building blocks in academia and industry. Due to the high energy associated with the diazonium group, many of these salts are reported as thermally unstable and/or unsafe to work with. However, most of the...

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Bibliographic Details
Published inProcess safety and environmental protection Vol. 177; pp. 69 - 81
Main Authors Souza, Edson Leonardo Scarpa de, Chorro, Tomaz Henrique Duarte, Correia, Carlos Roque Duarte
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.2023
Subjects
Arenediazonium Salts Stability
Differential Scanning Calorimetry
Pfizer Correlation
Thermoanalysis
Yoshida Correlation
Arenediazonium Salts Stability
Yoshida Correlation
Differential Scanning Calorimetry
Pfizer Correlation
Thermoanalysis
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Summary:Arenediazonium salts represent an important class of aromatic organic compounds widely used as building blocks in academia and industry. Due to the high energy associated with the diazonium group, many of these salts are reported as thermally unstable and/or unsafe to work with. However, most of the tetrafluoroborate arenediazonium salts are fairly stable to handle at room temperature both in solution and when dry. Nevertheless, some of these salts, especially those containing heteroatoms in the aromatic moiety, are problematic for their synthesis, and some are indeed highly unstable. To bring some light on this controversial subject, the thermal stability and potential hazards of the 58 most common arenediazonium tetrafluoroborate salts used by us over the last two decades were evaluated under careful conditions. These results are expected to guide conscious decisions on the use and handling of arenediazonium tetrafluoroborates in organic synthesis.
ISSN:0957-5820
1744-3598
DOI:10.1016/j.psep.2023.06.082