Effect of cimaterol on sheep adipose tissue lipid metabolism

• Published in: Journal of animal science Vol. 66; no. 6; p. 1393
• Main Authors: Hu, C.Y, Suryawan, A, Forsberg, N.E, Dalrymple, R.H, Ricks, C.A
• Format: Journal Article
• Language: English
• Published: United States 01.06.1988
• Subjects: ADDITIF AUX ALIMENTS DES ANIMAUX; Adipose Tissue - cytology; Adipose Tissue - drug effects; Adipose Tissue - metabolism; ADIPOSE TISSUES; ADITIVO DE PIENSOS; Adrenergic beta-Agonists - pharmacology; Animals; BETA-ADRENERGIC AGONISTS; DIET; DIETA; Ethanolamines - pharmacology; FEED ADDITIVES; Insulin - pharmacology; Lipid Metabolism; Lipids - biosynthesis; LIPOGENESE; LIPOGENESIS; LIPOLISIS; LIPOLYSE; LIPOLYSIS; Lipolysis - drug effects; Male; MEDICAMENT NEUROTROPE; MEDICAMENTOS NEUROTROPICOS; NEUROTROPIC DRUGS; OVIN; OVINOS; REGIME ALIMENTAIRE; SHEEP; Sheep - metabolism; TEJIDO ADIPOSO; TISSU ADIPEUX
• ISSN: 0021-8812; 1525-3163
• DOI: 10.2527/jas1988.6661393x

Effects of dietary cimaterol (5 mg/kg) on adipose tissue metabolism of wether lambs were studied. Lipogenesis, lipolysis, fatty acid composition and adipocyte size and number were measured. Cimaterol feeding increased lipogenesis; however, this effect was not statistically significant. Insulin (1,000 microU/ml) stimulated lipogenesis of adipose tissue from control sheep. However, this elevated rate was abolished by in vitro cimaterol. Insulin had no stimulatory effect on lipogenesis in cimaterol-fed sheep. Lipolysis was depressed by cimaterol feeding. However, 10(-4) M cimaterol stimulated lipolysis in the adipose tissue from both control and cimaterol-fed sheep. Insulin inhibited stimulated lipolysis in adipose tissue from control sheep but had no effect on the stimulated lipolysis in cimaterol-fed sheep. Mean adipocyte diameter was smaller (from 74 to 70 microns) and adipocyte size distribution also was changed in the cimaterol-fed sheep. Adipocyte number per gram of tissue was not affected by cimaterol. There was a significant increase in percentage of unsaturated fatty acids in adipose tissue from cimaterol-fed sheep. These results indicate that lipogenic and lipolytic responses to insulin and cimaterol in sheep adipose tissue were altered by cimaterol feeding. The carcass fat content decrease in cimaterol-fed sheep may be attributed to the reduction in adipocyte size.