Shared Principles in NF-κB Signaling

The transcription factor NF-κB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-κB, and the large number of genes regulated by NF-κB, ensure that this transcription factor is still the subject of intense research. Here, we att...

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Bibliographic Details
Published inCell Vol. 132; no. 3; pp. 344 - 362
Main Authors Hayden, Matthew S., Ghosh, Sankar
Format Journal Article
LanguageEnglish
Published Elsevier Inc 08.02.2008
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Summary:The transcription factor NF-κB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-κB, and the large number of genes regulated by NF-κB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-κB, and we aim to generate a more unified view of NF-κB regulation.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2008.01.020