Bone involvement in pediatric non-Hodgkin's lymphomas

Data pertaining to primary and secondary osseous involvement in pediatric non-Hodgkin's lymphoma (NHL) are scarce in English literature. Fifty-nine cases of childhood NHL over a period of 3·5 years were reviewed out of which eight had bone involvement, the incidence of skeletal involvement bein...

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Published inHematology (Luxembourg) Vol. 13; no. 6; pp. 348 - 351
Main Authors Bakhshi, Sameer, Singh, Preetpaul, Thulkar, Sanjay
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.12.2008
Subjects
Adolescent
Antineoplastic Agents - therapeutic use
BONE LYMPHOMA
Bone Neoplasms - drug therapy
Bone Neoplasms - epidemiology
CHEMOTHERAPY
Child
Child, Preschool
CLINICAL CHARACTERISTICS
Female
Humans
Incidence
Infant
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - epidemiology
Male
NON-HODGKIN'S LYMPHOMA
RADIOLOGIC FEATURES
Remission Induction
Retrospective Studies
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Summary:Data pertaining to primary and secondary osseous involvement in pediatric non-Hodgkin's lymphoma (NHL) are scarce in English literature. Fifty-nine cases of childhood NHL over a period of 3·5 years were reviewed out of which eight had bone involvement, the incidence of skeletal involvement being 13·6%. There were seven males (87·5%) and mean age was 9·9 years (range: 1-15 years). Two patients (25%) had primary bone lymphoma and six cases (75%) were classified as secondary bone lymphoma. Six patients who opted for treatment received chemotherapy; 4/6 (67%) patients are in complete remission at a median follow-up of 41 months (range 19-44 months). Bone involvement was more common in relapsed cases in comparison to de novo presentations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1607-8454
1607-8454
DOI:10.1179/102453308X343464