Large plantar wart caused by human papillomavirus-66 and resolution by topical cidofovir therapy

• Published in: Journal of the American Academy of Dermatology Vol. 43; no. 2; pp. 340 - 343
• Main Authors: Davis, Mark D.P., Gostout, Bobbie S., McGovern c, Renee M., Persing, David H., Schut, Ronald L., Pittelkow, Mark R.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.2000; Elsevier
• Subjects: Administration, Topical; Adult; AIDS-Related Opportunistic Infections - drug therapy; AIDS-Related Opportunistic Infections - pathology; AIDS-Related Opportunistic Infections - virology; AIDS/HIV; Antiviral Agents - administration & dosage; Biological and medical sciences; Biopsy; Cidofovir; Cytosine - administration & dosage; Cytosine - analogs & derivatives; Diagnosis, Differential; DNA, Viral - genetics; Female; Foot Dermatoses - drug therapy; Foot Dermatoses - pathology; Foot Dermatoses - virology; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Organophosphonates; Organophosphorus Compounds - administration & dosage; Papillomaviridae - drug effects; Papillomaviridae - genetics; Papillomavirus Infections - drug therapy; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; Polymerase Chain Reaction; Skin - pathology; Skin - virology; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Warts - drug therapy; Warts - pathology; Warts - virology; Infection; Case study; Human; Foot sole; Skin disease; Chemotherapy; Treatment; Wart; Viral disease; Antiviral; Cidofovir; Skin
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/S0190-9622(00)70287-8

Warts can be difficult to diagnose and to treat in the setting of human immunodeficiency virus (HIV) infection. A 37-year-old woman with a background of HIV presented with a large verrucous plaque involving her right foot. Human papillomavirus (HPV)-66 was identified in the lesional skin biopsy sample and in scrapings obtained from her cervix. The wart rapidly responded to topical cidofovir therapy. HPV-66 is a novel HPV type to be associated with verruca vulgaris. Topical cidofovir should be further investigated as an alternative treatment modality for verruca vulgaris. (J Am Acad Dermatol 2000;43:340-3)