The Preparation Of 2-[4,5-Dihydro-3-Aryl-5-Isoxazolyl]-Phenols From C(α),O-Dilithiooximes and Lithiated Hydroxyaryl Aldehydes

C(a), O-Oximes were dilithiated in excess lithium diisopropylamide, and the resulting intermediates were condensed with lithiated hydroxyphenyl aldehydes and related materials and cyclized with acid to afford 2-[4,5-dihydro-3-aryl-5-isoxazolyl]phenols, substituted 4,5-dihydroisoxazoles (2-isoxazolin...

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Bibliographic Details
Published inSynthetic communications Vol. 29; no. 11; pp. 1977 - 1988
Main Authors Williams, Angela R., Angel, April J., French, Kristen L., Hurst, Douglas R., Beckman, Darrell D., Beam, Charles F.
Format Journal Article
LanguageEnglish
Published NEW YORK Taylor & Francis Group 01.06.1999
Marcel Dekker Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
OXIMES
NITRILE OXIDES
ISOXAZOLINES
CHLORIDES
CONDENSATION
GENERATION
DEHYDROCHLORINATION
ALDOXIMES
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Summary:C(a), O-Oximes were dilithiated in excess lithium diisopropylamide, and the resulting intermediates were condensed with lithiated hydroxyphenyl aldehydes and related materials and cyclized with acid to afford 2-[4,5-dihydro-3-aryl-5-isoxazolyl]phenols, substituted 4,5-dihydroisoxazoles (2-isoxazolines).
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919908086186