Relationship of HLA-B51 and HLA-B52 alleles and TNF-α-308A/G polymorphism with susceptibility to Takayasu arteritis: a meta-analysis

• Published in: Clinical rheumatology Vol. 36; no. 1; pp. 173 - 181
• Main Authors: Chen, Si, Luan, Haixia, Li, Liubing, Zeng, Xiaoli, Wang, Tian, Li, Yongzhe, Yuan, Hui
• Format: Journal Article
• Language: English
• Published: London Springer London 01.01.2017
• Subjects: Alleles; Case-Control Studies; Genetic Predisposition to Disease; Genotype; HLA-B51 Antigen - genetics; HLA-B52 Antigen - genetics; Humans; Inflammation; Medicine; Medicine & Public Health; Original Article; Polymorphism, Genetic; Rheumatology; Sensitivity and Specificity; Takayasu Arteritis - genetics; Tumor Necrosis Factor-alpha - genetics; Takayasu arteritis; TNF-α; HLA; Meta-analysis; Polymorphism
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-016-3445-0

We performed a meta-analysis to determine whether combined evidence shows an association between HLA-B*51 and HLA-B*52 alleles and TNF-α-308A/G polymorphism and the susceptibility to Takayasu arteritis (TA). Relevant articles dated November 2015 were acquired from the PubMed, Embase and Cochrane databases. The number of genotypes and/or alleles for HLA-B*51 and HLA-B*52 alleles and TNF-α-308 A/G polymorphism in cases and control subjects was extracted, and statistical analysis was conducted using STATA 11.2 software. We included 20 studies with 1864 TA patients and 6973 controls. The HLA-B*52 allele was found to be associated with TA (pooled OR 3.91, 95 % CI 3.22–4.74, P  < 0.0001). The meta-analysis of TNF-α-308 A/G polymorphism for the A allele vs. G allele ( P  = 0.006) and AA + AG vs. GG ( P  = 0.023) revealed a significant association with TA. However, we did not find that the HLA-B*51 allele was associated with TA. This meta-analysis demonstrated that the HLA-B*52 allele and TNF-α-308 A/G polymorphism may contribute to TA susceptibility.