TRIMETHYLTIN(IV) COMPLEXES WITH SOME SELECTED DNA CONSTITUENTS

The interaction of the trimethyltin(IV) with some selected DNA constituents such as inosine, inosine 5′-monophosphate, adenine, adenosine, adenosine 5′-monophosphate, uracil, thymine, thymidine, cytosine and cytidine were investigated at 25°C and 0.1 M ionic strength in aqueous solutions and dioxane...

Full description

Saved in:
Bibliographic Details
Published inJournal of coordination chemistry Vol. 53; no. 2; pp. 125 - 142
Main Authors Mohamed, Mahmoud M. A., Shehata, Mohamed R., Shoukry, Mohamed M.
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.04.2001
Subjects
DNA complexes
Equilibrium studies
Speciation
Stability constants
Trimethyltin(IV) complexes
Online AccessGet full text

Cover

More Information
Summary:The interaction of the trimethyltin(IV) with some selected DNA constituents such as inosine, inosine 5′-monophosphate, adenine, adenosine, adenosine 5′-monophosphate, uracil, thymine, thymidine, cytosine and cytidine were investigated at 25°C and 0.1 M ionic strength in aqueous solutions and dioxane-water mixtures using potentiometry. The stepwise formation constants of the complexes formed in solution were calculated using the non-linear least-square program MINIQUAD-75. The concentration distribution of the various complex species was evaluated as a function of pH. The effect of dioxane as a solvent on the protonation constants of ligands and the formation constants of trimethyltin(IV) complexes were discussed. The thermodynamic parameters ΔH° and ΔS° calculated from the temperature dependence of the equilibrium constants were investigated.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958970108022607