Hypoxic sensitizers: radiobiological studies at the cellular level

The nitroimidazoles have been found to selectively sensitize hypoxic cells to the effects of irradiation. The latest in this family of drugs is RO-07-0582, which is able to mimic 80% of the oxygen effect at a concentration of 5 mM by modifying the sensitivity of hypoxic cells to single doses of gamm...

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Bibliographic Details
Published inRadiology Vol. 117; no. 2; p. 453
Main Authors Hall, E J, Roizin-Towle, L
Format Journal Article
LanguageEnglish
Published United States 01.11.1975
Subjects
Animals
Cell Survival - drug effects
Cell Survival - radiation effects
Cells, Cultured - drug effects
Cells, Cultured - radiation effects
Cricetinae
Nitroimidazoles - pharmacology
Oxygen
Radiation-Sensitizing Agents
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Summary:The nitroimidazoles have been found to selectively sensitize hypoxic cells to the effects of irradiation. The latest in this family of drugs is RO-07-0582, which is able to mimic 80% of the oxygen effect at a concentration of 5 mM by modifying the sensitivity of hypoxic cells to single doses of gamma rays; however, it is not a substitution for oxygen in promoting the repair of sublethal radiation damage between split doses. Studies show that it is a powerful cytotoxic agent as well and selectively operates against hypoxic cells.
ISSN:0033-8419
DOI:10.1148/117.2.453