The Syntheses, Structures, Fluorescence Properties and Biological Activity of two Novel Zinc(II) Complexes Controlled by the Tripodal Imidazole Ligand

• Published in: Journal of fluorescence Vol. 26; no. 4; pp. 1331 - 1339
• Main Authors: Gao, En-Jun, Zhang, Shaozhong, Meng, Yang, Zhao, Fu-Chen, Ma, Xiao-Yu, Jin, Hai-Tao, Liu, Si-Jia, Ge, Jing, Sun, Ya-Guang, Zhang, Wan-zhong, Zhu, Ming-Chang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2016
• Subjects: Analytical Chemistry; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedicine; Biophysics; Biotechnology; Chemistry Techniques, Synthetic; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; Coordination Complexes - metabolism; Coordination Complexes - pharmacology; DNA - metabolism; Humans; Imidazoles - chemistry; KB Cells; Ligands; Original Article; Spectrometry, Fluorescence; Zinc - chemistry; 3,5-di(1H-imidazol-1-yl)pyridine; Cancer cell inhibition; 1,3,5-tris(1-imidazolyl)benzene; Crystal structure
• ISSN: 1053-0509; 1573-4994
• DOI: 10.1007/s10895-016-1820-5

Two new zinc complexes, namely Zn(L 1 )ClCH 2 NO(1) and {Zn(L 2 )CH 2 NO} n ▪N(CH 3 ) 3 ▪ClO 4 (2) (L 1  = 3,5-di(1H-imidazol-1-yl)pyridine L 2  = 1,3,5-tris(1-imidazolyl) benzene), have been synthesized, and characterized by IR spectra, elemental analysis, and a single crystal X-ray diffraction. Fluorescence spectroscopy indicated that two complexes presented strong DNA binding affinity constants to fish sperm DNA (FS-DNA). Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic study showed the complex exhibited significant cancer cell(KB) inhibitory rate.