Association of Vitamin D deficiency and Vitamin D Receptor Gene Polymorphisms with Type 2 diabetes mellitus Saudi patients

• Published in: African health sciences Vol. 19; no. 4; pp. 2812 - 2818
• Main Author: Al-Hazmi, Ayman S
• Format: Journal Article
• Language: English
• Published: Uganda Makerere Medical School 01.12.2019
• Subjects: Adult; Case-Control Studies; Diabetes Mellitus, Type 2 - genetics; Genetic Association Studies; Humans; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Calcitriol - genetics; Vitamin D Deficiency - genetics; Vitamin D receptor; diabetes type 2; polymorphism
• ISSN: 1680-6905; 1729-0503; 1680-6905
• DOI: 10.4314/ahs.v19i4.2

Type 2 diabetes mellitus (T2DM) is a global problem. Association of multiple genes in T2DM becomes a hot point recently. This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with susceptibility to T2DM. One hundred T2DM Saudi male patients were included in this study and one hundred healthy Saudi men were used as control. For each individual, fasting blood glucose, cholesterol, HDL-C, LDL-C, HbA1c, insulin and 25-(OH) vitamin D were measured. In addition, and TaqI genotypes were performed for each subject. Data was analyzed by SPSS version 16, using Spearman's rho and ANOVA tests. There was significant inverse correlation between 25-(OH) vitamin D level and T2DM (p<0.01). HbA1c was inversely correlated with 25-(OH) vitamin D level (P<0.05). Genotype study showed that tt of TaqI genotype was higher in T2DM group compared with control group (p<0.05). Moreover, tt genotype has higher HbA1c than both TT and Tt genotypes (p<0.05). An association was confirmed between genotypes and T2DM but there is no correlation between BsmI, ApaI and T2DM. In addition, HbA1c is positively correlated with tt genotype of TaqI.