The role of trophic factors and inflammatory processes in physical activity-induced neuroprotection in Parkinson's disease

• Published in: Postȩpy higieny i medycyny doświadczalnej Vol. 71; no. 1; pp. 713 - 726
• Main Authors: Pałasz, Ewelina, Bąk, Agnieszka, Gąsiorowska, Anna, Niewiadomska, Grażyna
• Format: Journal Article
• Language: English
• Published: Poland 04.01.2017
• Subjects: Anti-Inflammatory Agents - therapeutic use; Exercise; Humans; Inflammation; Nerve Growth Factors; Neuroglia; Neuroprotection; Oxidative Stress; Parkinson Disease - therapy; czynnik wzrostu pochodzenia mózgowego - BDNF; procesy zapalne; choroba Parkinsona; czynnik wzrostu pochodzenia glejowego - GDNF; czynniki neurotroficzne; aktywność fizyczna; neuroprotekcja
• ISSN: 0032-5449; 1732-2693
• DOI: 10.5604/01.3001.0010.3850

Glial cells and neurotrophins play an important role in maintaining homeostasis of the CNS. Disturbances of their function can lead to a number of nervous system diseases, including Parkinson's disease (PD). Current clinical studies provide evidence that moderate physical activity adapted to the health status of PD patients can support pharmacological treatment, slow down the onset of motor impairments, and extend the patients period of independence. Physical activity, by stimulating the production and release of endogenous trophic factors, prevents the neurodegeneration of dopaminergic neurons via inhibition of inflammatory processes and the reduction of oxidative stress. The aim of this study is to present the current state of knowledge for the anti-inflammatory and neuroprotective properties of physical activity as a supportive therapy in Parkinson's disease.