A facile and practical preparation of P -chiral phosphine oxides

A practical and cost-effective synthetic method of P -chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed and well contr...

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Published inChemical communications (Cambridge, England) Vol. 57; no. 27; pp. 3335 - 3338
Main Authors Xu, Ronghua, Gao, Zhenhua, Yu, Yiteng, Tang, Yehua, Tian, Duanshuai, Chen, Tian, Chen, Yibing, Xu, Guangqing, Shi, Enxue, Tang, Wenjun
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.04.2021
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
cost effectiveness
Crystallography
phosphine
Phosphine oxide
Physical Sciences
Racemization
Reaction time
Science & Technology
solvents
Solvolysis
temperature
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Summary:A practical and cost-effective synthetic method of P -chiral diarylalkyl, aryldialkyl, and triaryl phosphine oxides by using readily available chiral diphenyl-2-pyrrolidinemethanol as the auxiliary is developed. The long-standing racemization issue during solvolysis has been addressed and well controlled by employing a suitable solvent, a low reaction temperature, and an appropriate reaction time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/D1CC00646K