Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities

• Published in: Wiener Klinische Wochenschrift Vol. 128; no. 17-18; pp. 641 - 648
• Main Authors: Figurová, Jana, Dravecká, Ingrid, Javorský, Martin, Petríková, Jana, Lazúrová, Ivica
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.09.2016
• Subjects: Adult; Comorbidity; Endocrinology; Female; Gastroenterology; Genital Diseases, Female - diagnosis; Genital Diseases, Female - epidemiology; Humans; Hyperandrogenism - diagnosis; Hyperandrogenism - epidemiology; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases - diagnosis; Metabolic Diseases - epidemiology; Original Article; Pneumology/Respiratory System; Polycystic Ovary Syndrome - diagnosis; Polycystic Ovary Syndrome - epidemiology; Prevalence; Risk Factors; Slovakia - epidemiology; Vitamin D Deficiency - diagnosis; Vitamin D Deficiency - epidemiology; Women's Health - statistics & numerical data; Polycystic ovary syndrome; Vitamin D deficiency; Insulin resistance; Hyperandrogenism
• ISSN: 0043-5325; 1613-7671
• DOI: 10.1007/s00508-015-0768-9

Summary Objective To investigate prevalence of vitamin D deficiency and its relation to clinical, anthropometrical, and biochemical findings in polycystic ovary syndrome (PCOS) and controls. Design Case-control prospective observational study. Settings Department of Internal medicine, L.P. University hospital . Patient(s) 99 PCOS women and 66 controls. Main outcome measure(s) 25-hydroxyvitamin D level (25(OH)D), anthropometric, endocrine, and metabolic parameters in both groups. Results There was no significant difference in 25(OH)D levels between PCOS women and controls (24.79 ± 10.77 vs 25.07 ± 10.14 ng/ml, p = 0.868) and also in the prevalence of 25(OH)D deficiency in both groups (80 vs 70 %; p = 0.138). Vitamin D-deficient PCOS patients had significantly higher body mass index (BMI), fasting insulin, and homeostasis model assessment-insulin resistance (median [quartiles]: 2.24 [1.38; 3.51] vs 1.23 [0.79; 1.66]; p < 0.05, age-and BMI-adjusted p = 0.036) and borderline higher glycemia (4.7 ± 0.5 vs 4.5 ± 0.4 mmol/l; p = 0.05; p_adj = 0.95) compared with vitamin D-deficient controls. PCOS women with metabolic syndrome (MS) had lower serum 25(OH)D compared with those without MS (20.6 ± 8.3 vs 25.9 ± 11.3 ng/ml, p = 0.049). 25(OH)D correlated positively with high-density lipoprotein cholesterol in all subjects ( r = 0.159, p = 0.043) and negatively with luteinizing hormone/follicle-stimulating hormone ratio ( r = − 0.211, p = 0.037). Conclusion Insulin resistance and other metabolic abnormalities in PCOS women seem to be related to PCOS rather than to vitamin D deficiency.