Serum Basic Fibroblastic Growth Factor Levels in Children with Infantile Hemangioma

• Published in: Indian journal of pediatrics Vol. 83; no. 9; pp. 937 - 940
• Main Authors: Tanyildiz, Hikmet Gulsah, Unal, Emel Cabi, Gokce, Hafize, Yavuz, Gulsan, Tacyildiz, Nurdan, Dincaslan, Handan, Gurman, Ceyda, Biyikli, Zeynep
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.09.2016
• Subjects: Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Fibroblast Growth Factor 2 - blood; Gynecology; Hemangioma, Capillary - diagnosis; Hemangioma, Capillary - therapy; Humans; Infant; Infant, Newborn; Medicine; Medicine & Public Health; Original Article; Patient Care Planning; Pediatrics; Hemangioma; Serum basic fibroblastic growth factor; Children
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-016-2041-2

Objectives To determine serum levels of basic fibroblastic growth factor (b-FGF) in hemangioma patients under 2 y of age. Methods The study group consisted of 43 children with infantile hemangioma and b-FGF levels were analyzed using ELISA. Results The serum b-FGF levels were higher in hemangioma patients than in healthy control individuals ( p 0.01). There were no differences between the lesion size, number of lesions, patient age and serum b-FGF levels. Conclusions Thus, b-FGF is an important growth factor that plays a central role in hemangioma, but determining b-FGF serum levels was not helpful in distinguishing between patients who require treatment and those who do not.