A biochemist's view of long-term potentiation

This review surveys the molecular mechanisms of long-term potentiation (LTP) from the point of view of a biochemist. On the basis of available data, LTP in area CA1 of the hippocampus is divided into three phases--initial, early, and late--and the mechanisms contributing to the induction and express...

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Published inLearning & memory (Cold Spring Harbor, N.Y.) Vol. 3; no. 1; pp. 1 - 24
Main Authors Roberson, E D, English, J D, Sweatt, J D
Format Journal Article
LanguageEnglish
Published United States 01.07.1996
Subjects
Animals
Biochemistry - methods
Hippocampus - metabolism
Humans
Long-Term Potentiation - physiology
Models, Biological
Second Messenger Systems - physiology
Signal Transduction - physiology
Time Factors
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Summary:This review surveys the molecular mechanisms of long-term potentiation (LTP) from the point of view of a biochemist. On the basis of available data, LTP in area CA1 of the hippocampus is divided into three phases--initial, early, and late--and the mechanisms contributing to the induction and expression of each phase are examined. We focus on evidence for the involvement of various second messengers and their effectors as well as the biochemical strategies employed in each phase to convert a transient signal into a lasting change in the neuron. We also consider, from a biochemical perspective, the implications of a multiphase model for LTP.
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ISSN:1072-0502
1549-5485
DOI:10.1101/lm.3.1.1