Human surfactant proteins A2 (SP-A2) and B (SP-B) genes as determinants of respiratory distress syndrome

Objective To study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. Design Cross-sectional. Setting Neonatal intensive care unit and the Molecular Biology unit of the Chemical Pathology Department, Kasr Alainy hospital, Cairo Universit...

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Published inIndian pediatrics Vol. 52; no. 5; pp. 391 - 394
Main Authors Abuelhamed, Walaa A., Zeidan, Nancy, Shahin, Walaa A., Rizk, Hoda I., Rabie, Walaa A.
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 01.05.2015
Subjects
Cross-Sectional Studies
Egypt - epidemiology
Female
Genetic Predisposition to Disease - genetics
Humans
Infant, Newborn
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Polymorphism, Single Nucleotide - genetics
Pregnancy
Pulmonary Surfactant-Associated Protein A - genetics
Pulmonary Surfactant-Associated Protein B - genetics
Research Paper
Respiratory Distress Syndrome, Newborn - epidemiology
Respiratory Distress Syndrome, Newborn - genetics
Egypt
Surfactant protein
Neonate
Respiratory distress syndrome
Polymorphisms
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Abstract Objective To study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. Design Cross-sectional. Setting Neonatal intensive care unit and the Molecular Biology unit of the Chemical Pathology Department, Kasr Alainy hospital, Cairo University. Participants Sixty-five preterm infants with respiratory distress syndrome and 50 controls. The genomic DNA was isolated using DNA extraction kits. SYBR Greenbased real-time PCR was used to determine the variant genotypes of SP-A2 c.751 G<A and SP-B c.8714 G<C single nucleotide polymorphisms. Results Homozygosity of SP-A (OR 46, 95% CI 14–151) and SP-B (OR 5.2, 95% CI 2.3–11.4) alleles increased the risk of respiratory distress syndrome. The logistic regression model showed that genotypes SP-A2 (OR 164) and SP-B (OR 18) were directly related to the occurrence of respiratory distress syndrome, whereas gestational age (OR 0.57) and 5-minute Apgar score (OR 0.19) were inversely related to its occurrence. Conclusions There is a possible involvement of SP-A2 and SP-B genes polymorphisms in the genetic predisposition to respiratory distress syndrome.
AbstractList To study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. Cross-sectional. Neonatal intensive care unit and the Molecular Biology unit of the Chemical Pathology Department, Kasr Alainy hospital, Cairo University. Sixty-five preterm infants with respiratory distress syndrome and 50 controls. The genomic DNA was isolated using DNA extraction kits. SYBR Green-based real-time PCR was used to determine the variant genotypes of SP-A2 c.751 G>A and SP-B c.8714 G>C single nucleotide polymorphisms. Homozygosity of SP-A (OR 46, 95% CI 14-151) and SP-B (OR 5.2, 95% CI 2.3-11.4) alleles increased the risk of respiratory distress syndrome. The logistic regression model showed that genotypes SP-A2 (OR 164) and SP-B (OR 18) were directly related to the occurrence of respiratory distress syndrome, whereas gestational age (OR 0.57) and 5-minute Apgar score (OR 0.19) were inversely related to its occurrence. There is a possible involvement of SP-A2 and SP-B genes polymorphisms in the genetic predisposition to respiratory distress syndrome.
Objective To study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. Design Cross-sectional. Setting Neonatal intensive care unit and the Molecular Biology unit of the Chemical Pathology Department, Kasr Alainy hospital, Cairo University. Participants Sixty-five preterm infants with respiratory distress syndrome and 50 controls. The genomic DNA was isolated using DNA extraction kits. SYBR Greenbased real-time PCR was used to determine the variant genotypes of SP-A2 c.751 G<A and SP-B c.8714 G<C single nucleotide polymorphisms. Results Homozygosity of SP-A (OR 46, 95% CI 14–151) and SP-B (OR 5.2, 95% CI 2.3–11.4) alleles increased the risk of respiratory distress syndrome. The logistic regression model showed that genotypes SP-A2 (OR 164) and SP-B (OR 18) were directly related to the occurrence of respiratory distress syndrome, whereas gestational age (OR 0.57) and 5-minute Apgar score (OR 0.19) were inversely related to its occurrence. Conclusions There is a possible involvement of SP-A2 and SP-B genes polymorphisms in the genetic predisposition to respiratory distress syndrome.
OBJECTIVETo study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates.DESIGNCross-sectional.SETTINGNeonatal intensive care unit and the Molecular Biology unit of the Chemical Pathology Department, Kasr Alainy hospital, Cairo University.PARTICIPANTSSixty-five preterm infants with respiratory distress syndrome and 50 controls. The genomic DNA was isolated using DNA extraction kits. SYBR Green-based real-time PCR was used to determine the variant genotypes of SP-A2 c.751 G>A and SP-B c.8714 G>C single nucleotide polymorphisms.RESULTSHomozygosity of SP-A (OR 46, 95% CI 14-151) and SP-B (OR 5.2, 95% CI 2.3-11.4) alleles increased the risk of respiratory distress syndrome. The logistic regression model showed that genotypes SP-A2 (OR 164) and SP-B (OR 18) were directly related to the occurrence of respiratory distress syndrome, whereas gestational age (OR 0.57) and 5-minute Apgar score (OR 0.19) were inversely related to its occurrence.CONCLUSIONSThere is a possible involvement of SP-A2 and SP-B genes polymorphisms in the genetic predisposition to respiratory distress syndrome.
Author Rizk, Hoda I.
Shahin, Walaa A.
Zeidan, Nancy
Abuelhamed, Walaa A.
Rabie, Walaa A.
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CitedBy_id crossref_primary_10_3389_fped_2022_851042
crossref_primary_10_1097_MD_0000000000029701
crossref_primary_10_3389_fimmu_2023_1328658
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Keywords Surfactant protein
Neonate
Respiratory distress syndrome
Polymorphisms
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Snippet Objective To study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. Design Cross-sectional....
To study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. Cross-sectional. Neonatal intensive...
OBJECTIVETo study the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm...
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springer
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StartPage 391
SubjectTerms Cross-Sectional Studies
Egypt - epidemiology
Female
Genetic Predisposition to Disease - genetics
Humans
Infant, Newborn
Maternal and Child Health
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Polymorphism, Single Nucleotide - genetics
Pregnancy
Pulmonary Surfactant-Associated Protein A - genetics
Pulmonary Surfactant-Associated Protein B - genetics
Research Paper
Respiratory Distress Syndrome, Newborn - epidemiology
Respiratory Distress Syndrome, Newborn - genetics
Title Human surfactant proteins A2 (SP-A2) and B (SP-B) genes as determinants of respiratory distress syndrome
URI https://link.springer.com/article/10.1007/s13312-015-0643-9
https://www.ncbi.nlm.nih.gov/pubmed/26061924
https://search.proquest.com/docview/1687997767
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