Cylindrical Splitt and Quadrupole Magnetic Field in Application to Continuous-Flow Magnetic Cell Sorting

The quadrupole magnetic field has been used for quadrupole mass spectroscopy and for industrial and mining dry separations. We propose to use it for rapid, continuous-flow cell sorting in biomedical and biotechnological applications. We set out to investigate the performance of such a sorter using t...

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Bibliographic Details
Published inJournal of liquid chromatography & related technologies Vol. 20; no. 16-17; pp. 2887 - 2905
Main Authors Zborowski, M., Williams, P. S., Sun, L., Moore, L. R., Chalmers, J. J.
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.09.1997
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Summary:The quadrupole magnetic field has been used for quadrupole mass spectroscopy and for industrial and mining dry separations. We propose to use it for rapid, continuous-flow cell sorting in biomedical and biotechnological applications. We set out to investigate the performance of such a sorter using the theoretical methods of split-flow thin channel separation (SPLITT). Comparison of theoretical results and preliminary experimental data, using a model system of human peripheral lymphocytes labeled with immunomagnetic colloid, led us to the identification of the most important parameters of the system.
ISSN:1082-6076
1520-572X
DOI:10.1080/10826079708005599