Micro or nano: Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

• Published in: Nano research Vol. 13; no. 2; pp. 511 - 526
• Main Authors: Zhu, Zhou, Jiang, Shaokang, Liu, Yanhua, Gao, Xiaomeng, Hu, Shanshan, Zhang, Xin, Huang, Chao, Wan, Qianbing, Wang, Jian, Pei, Xibo
• Format: Journal Article
• Language: English
• Published: Beijing Tsinghua University Press 01.02.2020
• Subjects: Angiogenesis; Atomic/Molecular Structure and Spectra; Biocompatibility; Biomedical materials; Biomedicine; Biosafety; Biotechnology; Cardiotoxicity; Chemistry and Materials Science; Comminution; Condensed Matter Physics; Evaluation; Magnesium; Materials Science; Metal-organic frameworks; Nanotechnology; Osteogenesis; Particle size; Research Article; Size reduction; Toxicity; magnesium metal organic framework-74; micron/nanoscale; biological applications; osteogenesis; angiogenesis
• ISSN: 1998-0124; 1998-0000
• DOI: 10.1007/s12274-020-2642-y

In recent years, various particulate materials have played important roles in medical applications. However, nano- and micron-sized particles of the same material could exhibit distinct properties due to different particle sizes. This finding provided a simple and effective way to improve the biological applications of particulate materials. Therefore, as a highly promising member, the effect of the particle size change of the magnesium metal organic framework-74 (Mg-MOF74) was well worth evaluating. Here we firstly assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74 (m-Mg-MOF74/n-Mg-MOF74) in detail. Our in vitro study revealed that compared to micron-sized subjects, n-Mg-MOF74 provided a wider range of safe concentrations. Furthermore, both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods, with n-Mg-MOF74 still showing lower cardiotoxicity. These advantages of nanoscale Mg-MOF74 might benefit from its sustainable and balanced release of Mg 2+ both inside and outside the cells. Based on the biosafety evaluation, advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were also performed. Similarly, the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation effects. Overall, our combined data delineated the toxicity and biological behaviors of Mg-MOF74 of different scales, and suggested nanoscale Mg-MOF74 as a better choice for future applications. This result revealed that particle size reduction might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.