Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma

• Published in: Anticancer research Vol. 37; no. 4; pp. 1923 - 1929
• Main Authors: Abe, Sosei, Yamashita, Shin-Ichi, Miyahara, S O, Wakahara, Junichi, Yamamoto, Leona, Mori, Ryo, Imamura, Naoko, Yoshida, Yasuhiro, Waseda, Ryuichi, Hiratsuka, Masafumi, Shiraishi, Takeshi, Nabeshima, Kazuki, Iwasaki, Akinori
• Format: Journal Article
• Language: English
• Published: Greece 01.04.2017
• Subjects: Aged; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - therapy; Combined Modality Therapy; Female; Humans; Immunoenzyme Techniques; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Lymphatic Metastasis; Male; Middle Aged; Mitogen-Activated Protein Kinase 7 - metabolism; Neoplasm Invasiveness; Neoplasm Staging; Polycomb Repressive Complex 1 - metabolism; Prognosis; Retrospective Studies; Survival Rate; BMI-1; MEL-18; prognosis; Lung cancer; squamous cell carcinoma
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.11531

We investigated the possibility of BMI-1 and MEL-18 to predict survival in patients with pulmonary squamous cell carcinoma. One hundred and ninety-nine patients underwent surgery in our Institute between 1995 and 2005. We used immunohistochemical (IHC) analysis to determine the expressions of BMI-1 and MEL-18 and compared them with clinicopathological factors and survival. Forty-one of 199 cases (21%) were BMI-1-positive. No correlation was found between BMI-1 and MEL-18 expression by IHC and clinicopathological factors. Five-year overall survival in the BMI-1-positive group (66.8%), but not MEL-18, was significantly better than that in the negative group (45.5%, p=0.04). In multivariate analysis, positive BMI-1 was a better prognostic factor of overall survival (hazard ratio (HR)=0.561, 95% confidence interval (CI)=0.271-1.16, p=0.12). BMI-1 expression, but not MEL-18, is associated with a favorable prognosis and is a possible prognostic factor of pulmonary squamous cell carcinoma.