A convenient One-Pot Synthesis of an Unsymmetrical Propane-1,3-diamine BRL 61010A

The one-pot condensation of N-methylhomoveratrylamine with acrolein followed by in situ reductive amination with 3,4-dimethoxyaniline to give an unsymmetrical propane 1,3-diamine in excellent yield is described.

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Bibliographic Details
Published inSynthetic communications Vol. 29; no. 5; pp. 827 - 833
Main Authors Attrill, Robin P, Ramsay, Thomas W, Slater, Graham R, Smith, Paul
Format Journal Article
LanguageEnglish
Published NEW YORK Taylor & Francis Group 01.03.1999
Marcel Dekker Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BETA-AMINO ALDEHYDES
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Summary:The one-pot condensation of N-methylhomoveratrylamine with acrolein followed by in situ reductive amination with 3,4-dimethoxyaniline to give an unsymmetrical propane 1,3-diamine in excellent yield is described.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919908086040