Studies on a heterologous complex formed by human butyrylcholinesterase

An electrophoretic band with butyrylcholinesterase activity was detected in 71 CHE2 C5+ and 378 CHE2 C5- individuals and was named C4/5 in view of its similar mobility to either C4 or C5, depending on the pH of the agar gel used. The present data suggest that C4/5 is a heterologous complex of butyry...

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Published inBiochemical genetics Vol. 41; no. 5-6; pp. 141 - 150
Main Authors Souza, R L R, Furtado, L, Diniz, A C P, Silva, A C D, Kaiss, J, Petzl-Erler, M L, Chautard-Freire-Maia, E A
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.06.2003
Subjects
Agar
Butyrylcholinesterase - blood
Butyrylcholinesterase - chemistry
Butyrylcholinesterase - genetics
Data processing
Electrophoresis
Electrophoresis, Agar Gel
Electrophoretic mobility
Genetic Variation - genetics
Humans
Hydrogen-Ion Concentration
pH effects
Phenotype
Saline Solution, Hypertonic - pharmacology
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Summary:An electrophoretic band with butyrylcholinesterase activity was detected in 71 CHE2 C5+ and 378 CHE2 C5- individuals and was named C4/5 in view of its similar mobility to either C4 or C5, depending on the pH of the agar gel used. The present data suggest that C4/5 is a heterologous complex of butyrylcholinesterase. Although the C4/5 band may have the same mobility as C5, depending on the conditions of electrophoresis, our hypothesis is that these two bands result from the association of BChE with different molecules.
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ISSN:0006-2928
1573-4927
DOI:10.1023/A:1023373526230