A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females

• Published in: Archives of osteoporosis Vol. 12; no. 1; p. 85
• Main Authors: Sulimani, Riad A., Mohammed, Ashry G., Alshehri, Suliman N., Alfadda, Assim A., Al-Othman, Abdulaziz, Khan, Aliya A.
• Format: Journal Article
• Language: English
• Published: London Springer London 30.09.2017
• Subjects: Adolescent; Adolescent Health Services; Biomarkers - blood; Bone Remodeling; Cholecalciferol - administration & dosage; Cholecalciferol - therapeutic use; Collagen Type I - blood; Dietary Supplements; Drug Administration Schedule; Endocrinology; Female; Humans; Medicine; Medicine & Public Health; Orthopedics; Osteocalcin - blood; Parathyroid Hormone - blood; Peptides - blood; Saudi Arabia; Short Communication; Surveys and Questionnaires; Vitamin D Deficiency - blood; Vitamin D Deficiency - drug therapy; Adolescents; Vitamin D deficiency; Bone turnover markers
• ISSN: 1862-3522; 1862-3514
• DOI: 10.1007/s11657-017-0379-3

Summary This study examined the effects of weekly 35,000 IU vitamin D supplementation for 4 weeks on bone turnover markers (BTMs). There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (βCTX) which paralleled the increase in vitamin D levels. Purpose The effects of vitamin D supplementation on bone turnover markers (BTMs) have been inconsistent. This study examined the effects of weekly 35,000 IU vitamin D supplementation for 1 month on BTMs. Methods Sixty-eight vitamin D deficient adolescent females were given 35,000 IU of vitamin D3 for 4 weeks. Pre and post intervention blood samples were taken for 25(OH) D, PTH, osteocalcin and βCTX. Results There was a significant increase in serum 25 (OH) D in the post intervention period which was accompanied by a significant decrease in PTH, osteocalcin and βCTX ( P  < 0.001). Conclusions We concluded that weekly 35,000 IU vitamin D supplementation for 4 weeks results in significant improvement of BTMs.