Generation of an iPSC line from a 79-year-old female patient diagnosed with sporadic Parkinson’s disease

Parkinson’s disease is a common neurodegenerative disorder. Here we present a human induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient diagnosed with sporadic Parkinson’s disease using the sendai virus. Generated iPSCs maint...

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Published inStem cell research Vol. 78; p. 103450
Main Authors Liu, Jingrui, Du, Juan, Ma, Xiaowei, Jin, Yuchuan, Yang, Qian, Zhai, Yingtong, Cheng, Jingke, Luan, Feng, Ma, Min, Zhang, Zhanchi, Ren, Qian, Cui, Huixian
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.08.2024
Elsevier
Subjects
Aged
Cell Differentiation
Cell Line
Female
Humans
Induced Pluripotent Stem Cells - metabolism
Karyotype
Leukocytes, Mononuclear - cytology
Parkinson Disease - diagnosis
Parkinson Disease - pathology
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Summary:Parkinson’s disease is a common neurodegenerative disorder. Here we present a human induced pluripotent stem cells (iPSCs) derived from peripheral blood mononuclear cells (PBMCs) of a 79-year-old female patient diagnosed with sporadic Parkinson’s disease using the sendai virus. Generated iPSCs maintain normal karyotype, exhibit pluripotent stem cell markers, and possess differentiation potential. The iPSCs allows for differentiation into various cell subtypes, providing conditions for the research of the pathogenesis and drug development of Parkinson’s disease.
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ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103450