Influence of the size and the morphology of ZnO nanoparticles on cell viability

Zinc oxide has attracted wide research interest due to its unique properties. Its band gap width, high refractive index, high electrical conductivity, and high optical transmission in the visible, etc., have made it suitable for a variety of applications, such as gas sensors, varistors, optoelectron...

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Published inComptes rendus. Chimie Vol. 18; no. 12; pp. 1335 - 1343
Main Authors Vasile, Otilia Ruxandra, Serdaru, Ioana, Andronescu, Ecaterina, Truşcă, Roxana, Surdu, Vasile Adrian, Oprea, Ovidiu, Ilie, Andreia, Vasile, Bogdan Ştefan
Format Journal Article
LanguageEnglish
Published Elsevier SAS 01.12.2015
Subjects
Cell viability
Cytotoxicity
Nanopowders
TEM
ZnO
Cytotoxicity
Cell viability
Nanopowders
ZnO
TEM
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Summary:Zinc oxide has attracted wide research interest due to its unique properties. Its band gap width, high refractive index, high electrical conductivity, and high optical transmission in the visible, etc., have made it suitable for a variety of applications, such as gas sensors, varistors, optoelectronic devices, etc. The first part of the paper presents three methods for the synthesis of zinc oxide nanoparticles: sol–gel, polyol, and hydrothermal methods. Then, we report on the characteristics of the powders in terms of structure, composition and morphology as well as of in-vitro testing on cell cultures. The influence of the nanoparticles on cell viability was evaluated by the lactate dehydrogenase method. It turns out that all ZnO powders tested present high cytotoxicity. Also, it is found that the synthesis method significantly influences cell viability, the lowest one being obtained for nanopowders synthesized by the sol–gel method.
ISSN:1631-0748
1878-1543
1878-1543
DOI:10.1016/j.crci.2015.08.005