Reaction of Mercaptoacetate and Halides Containing Activated Methylenes with Thiocarbamoylimidates: A Novel Approach to the Synthesis of Aminothiazole Derivatives

The reaction of N-thiocarbamoylimidates 1 with methyl thioglycolate leads to the formation of 4-arylamino-5-methoxycarbonylthiazoles 2. The condensation of the same imidates 1 on ethyl bromoacetate, benzyl bromide and chloroacetonitrile provides the corresponding 2-arylaminothiazoles 4.

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Bibliographic Details
Published inSynthetic communications Vol. 28; no. 1; pp. 167 - 174
Main Authors Dridi, K., EL Efrit, M. L., Baccar, B., Zantour, H.
Format Journal Article
LanguageEnglish
Published NEW YORK Taylor & Francis Group 01.01.1998
Marcel Dekker Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:The reaction of N-thiocarbamoylimidates 1 with methyl thioglycolate leads to the formation of 4-arylamino-5-methoxycarbonylthiazoles 2. The condensation of the same imidates 1 on ethyl bromoacetate, benzyl bromide and chloroacetonitrile provides the corresponding 2-arylaminothiazoles 4.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919808005086