Nanosized Particles of Tantalum, Hafnium, and Cerium Oxides Used with Monochromatic Photon Beams and Brachytherapy Sources

High- Z nanoparticles can increase the absorbed radiation dose if they are accumulated in tumor cells. The quantitative measure of this radiosensitization effect is the dose enhancement factor (DEF), that is, the ratio of the doses absorbed in the presence and in the absence of nanoparticles. In the...

Full description

Saved in:
Bibliographic Details
Published inOptics and spectroscopy Vol. 125; no. 1; pp. 104 - 106
Main Authors Morozov, V. N., Belousov, A. V., Krusanov, G. A., Kolyvanova, M. A., Krivoshapkin, P. V., Vinogradov, V. V., Chernyaev, A. P., Shtil, A. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2018
Springer Nature B.V
Subjects
07 ISOTOPES AND RADIATION SOURCES
ABSORBED RADIATION DOSES
BRACHYTHERAPY
CERAMICS
CERIUM OXIDES
CESIUM 131
CONCENTRATION RATIO
ENERGY SOURCES
Hafnium oxide
HAFNIUM OXIDES
IODINE 125
KEV RANGE 10-100
Lasers
MONOCHROMATIC RADIATION
NANOPARTICLES
Nanophotonics
NANOSCIENCE AND NANOTECHNOLOGY
NANOSTRUCTURES
Optical Devices
Optics
PALLADIUM 103
Particle beams
PHOTON BEAMS
Photonics
Physics
Physics and Astronomy
Radiation dosage
Radiation therapy
TANTALUM OXIDES
TUMOR CELLS
X RADIATION
Online AccessGet full text

Cover

More Information
Summary:High- Z nanoparticles can increase the absorbed radiation dose if they are accumulated in tumor cells. The quantitative measure of this radiosensitization effect is the dose enhancement factor (DEF), that is, the ratio of the doses absorbed in the presence and in the absence of nanoparticles. In the present work, the values of the dose enhancement factors of Ta 2 O 5 , HfO 2 , and CeO 2 ceramic nanoparticles were calculated analytically for monochromatic radiation of the X-ray energy range (1–180 keV) and for low-energy sources for brachytherapy: 103 Pd (mean energy, 20.6 keV), 125 I (26.7 keV), and 131 Cs (30.4 keV). For all types of nanoparticles in the concentration of 5 mg/mL, the values of the dose enhancement factor were high both for monochromatic radiation and for brachytherapy sources. The highest DEF values of ~1.7 were obtained for nanoparticles of tantalum oxide. For brachytherapy sources, the highest dose enhancement factors (1.48 to 1.67) were obtained for Ta 2 O 5 and HfO 2 nanoparticles. These results confirm that ceramic nanoparticles are promising dose modifying agents for radiotherapy.
ISSN:0030-400X
1562-6911
DOI:10.1134/S0030400X18070196