Development and validation of HPLC method for analysis of some antiretroviral agents in their pharmaceutical dosage forms

Anew analytical method using reversed-phase high performance liquid chromatography (HPLC) has been developed for analysis of four antiretroviral molecules Lamivudine, Abacavir, Zidovudine, and Efavirenz. The proposed method was validated in accordance with the ICH Q2 (R1) validation guidelines by de...

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Published inPharmaceutical chemistry journal Vol. 43; no. 6; pp. 369 - 374
Main Authors Garg, Abhinav, Kumar Soni, Love, Kaskhedikar, Satish G, Srinivas, Kona S, Singh, Loveraj, Gupta, Kamal K, Dwivedi, Dhananjay
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.06.2009
Springer US
Subjects
analytical method development
antiretroviral agents
HIV
HPLC
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
antiretroviral agents
HIV
analytical method development
HPLC
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Summary:Anew analytical method using reversed-phase high performance liquid chromatography (HPLC) has been developed for analysis of four antiretroviral molecules Lamivudine, Abacavir, Zidovudine, and Efavirenz. The proposed method was validated in accordance with the ICH Q2 (R1) validation guidelines by determining its selectivity, linearity, accuracy, and precision. Based on the results, the method is an effective choice to analyze these drugs in their single and combined pharmaceutical dosage forms.
Bibliography:http://dx.doi.org/10.1007/s11094-009-0305-0
ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-009-0305-0