Adjuvant sildenafil therapy in poor responders undergoing in vitro fertilization: A prospective, randomized, double-blind, placebo-controlled trial

Objective: To evaluate the effect of adjuvant sildenafil on ovarian responsiveness in low responders undergoing IVF. Patient(s) and methods: Prospective randomized, double-blind, placebo controlled study was conducted at Obstetrics and Gynecology department, Tanta university hospital and Center of A...

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Published inMiddle East Fertility Society journal Vol. 21; no. 3; pp. 175 - 179
Main Authors Ataalla, Walid M., Elhamid, Tarek abd, Elhalwagy, Ahmed Elsayed
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2016
Subjects
IVF
Poor responders
Sildenafil
IVF
Poor responders
Sildenafil
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Summary:Objective: To evaluate the effect of adjuvant sildenafil on ovarian responsiveness in low responders undergoing IVF. Patient(s) and methods: Prospective randomized, double-blind, placebo controlled study was conducted at Obstetrics and Gynecology department, Tanta university hospital and Center of Assisted Reproduction, Om El-kora Hospital, Tanta, Egypt. Sixty patients were classified as low responders undergoing IVF. Supplementation with sildenafil (50mg daily) or placebo to a gonadotropin releasing hormone antagonist protocol was provided. Result(s): There were no significant differences in total number of 75IU FSH ampoules used (60.025±5.52) versus (66.025±4.51), the number of mature follicles recruited (3.35±1.137) versus (2.95±.826), and the number of oocytes retrieved (3.95±1.395) versus (3.65±1.137) or cycle cancelation rates (26.7% in the treatment group versus 23.3% in placebo group). Conclusion: Adjuvant sildenafil does not enhance ovarian responsiveness in cases of previous low ovarian response to controlled ovarian hyperstimulation.
ISSN:1110-5690
DOI:10.1016/j.mefs.2015.12.004