Synthesis And Binding Study Of Phosphonate Analogues Of Pnas And Their Hybrids With Pnas

The preparation of monomers for the synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been ccomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono-PNA...

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Bibliographic Details
Published inNucleosides & nucleotides Vol. 17; no. 9-11; pp. 1671 - 1679
Main Authors Efimov, Vladimir A., Choob, Michael V., Buryakova, Alla A., Chakhmakhcheva, Oksana G.
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.09.1998
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Summary:The preparation of monomers for the synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been ccomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono-PNA oligomers as well as chimeras consisting of phosphono-PNA and PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319808004700