SYNTHESIS OF SOME NEW 1,2,4-TRIAZOLO[3,4-b]-THIADIAZOLE DERIVATIVES AS POSSIBLE ANTICANCER AGENTS

3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with carboxylic acids gives fused five-membered derivatives, whereas with α-bromoketones gives a six-membered heterocycle. In this article we report th...

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Published inPhosphorus, sulfur, and silicon and the related elements Vol. 179; no. 8; pp. 1595 - 1603
Main Authors Bhat, K. Subrahmanya, Prasad, D. Jagadeesh, Poojary, Boja, Holla, B. Shivarama
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis Group 01.08.2004
Taylor & Francis
Subjects
Anticancer activity
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
phosphorus oxychloride
Physical Sciences
Science & Technology
triazolothiadiazoles
IN-VITRO
DRUG DISCOVERY
THIADIAZOLOTRIAZINONES
NATIONAL-CANCER-INSTITUTE
triazolothiadiazoles
anticancer activity
phosphorus oxychloride
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Summary:3-Substituted-4-amino-5-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Their cyclization with carboxylic acids gives fused five-membered derivatives, whereas with α-bromoketones gives a six-membered heterocycle. In this article we report the synthesis of a series of 1,2,4-triazolo[3,4-b]thiadiazoles 5 starting from 4-amino-3-substituted-5-mercapto-1,2,4-triazoles 3 and fluorobenzoic acids 4 using phosphorous oxychloride as cyclizing agent. Fourteen of the newly synthesized compounds were screened for anticancer properties. Four among them showed in vitro anticancer activity.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500490464186