Synthesis and Biological Evaluation of 2′,3′-Dideoxy-3′-Fluororibofuranosyl Purine Nucleosides

Synthesis of 9-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2-chloroadenine (7b) and -2-chloro-6-methoxypurine (9b), as well as the α-D-anomer 7a of the former and its N isomer 10a is reported. Among the compounds synthesized, only the β-D-anomer 7b displays moderate cytotoxic activity.

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Bibliographic Details
Published inNucleosides & nucleotides Vol. 16; no. 7-9; pp. 1083 - 1086
Main Authors Poopeiko, Nicolai E., Khripach, Natalia B., Kazimierczuk, Zygmunt, Balzarini, Jan, De Clercq, Erik, Mikhailopulo, Igor A.
Format Journal Article
LanguageEnglish
Published Taylor & Francis Group 01.07.1997
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Summary:Synthesis of 9-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2-chloroadenine (7b) and -2-chloro-6-methoxypurine (9b), as well as the α-D-anomer 7a of the former and its N isomer 10a is reported. Among the compounds synthesized, only the β-D-anomer 7b displays moderate cytotoxic activity.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319708006137