Study of CuI catalyzed coupling reactions of aryl bromides with imidazole and aliphatic amines under microwave dielectric heating

Amination of a variety of functionalized aryl bromides with imidazole and primary and secondary amines was accomplished using a CuI/amino acid catalyst system under microwave heating. Application of microwave irradiation shortened the reaction time from 25–40 h to 6–20 min. Good to very good yields...

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Bibliographic Details
Published inChemical papers Vol. 62; no. 3; pp. 334 - 338
Main Authors Veverková, Eva, Toma, Štefan
Format Journal Article
LanguageEnglish
Published Heidelberg SP Versita 01.06.2008
Versita
Subjects
arylamines
Biochemistry
Biotechnology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
coupling reactions
CuI/amino acid catalysis
Industrial Chemistry/Chemical Engineering
Materials Science
Medicinal Chemistry
microwave irradiation
Short Communication
arylamines
microwave irradiation
CuI/amino acid catalysis
coupling reactions
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Summary:Amination of a variety of functionalized aryl bromides with imidazole and primary and secondary amines was accomplished using a CuI/amino acid catalyst system under microwave heating. Application of microwave irradiation shortened the reaction time from 25–40 h to 6–20 min. Good to very good yields of the corresponding coupling products were obtained when imidazole and secondary amines were used as starting materials. In case of primary amines, the outcome of the reaction was dependent on the character of the substituent on aryl bromide.
ISSN:0366-6352
1336-9075
1336-9075
DOI:10.2478/s11696-008-0033-z