Chemical composition, antioxidant activity and acetylcholinesterase inhibitory of wild Mentha species from northeastern Algeria

• Published in: South African journal of botany Vol. 116; pp. 131 - 139
• Main Authors: Benabdallah, A., Boumendjel, M., Aissi, O., Rahmoune, C., Boussaid, M., Messaoud, C.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2018
• Subjects: Acetylcholinesterase inhibitory; Algeria; Antioxidant; Essential oil; Mentha species; Acetylcholinesterase inhibitory; Essential oil; Algeria; Mentha species; Antioxidant
• ISSN: 0254-6299; 1727-9321
• DOI: 10.1016/j.sajb.2018.03.002

The aim of this work is to evaluate the chemical composition and biological activities of essential oils obtained from aerial parts of six wild Algerian Mentha species (M. aquatica, M. arvensis, M. x piperita, M. pulegium, M. rotundifolia and M. x villosa), collected from the National Park of El-Kala. Chemical composition was analyzed by GC‐MS, the DPPH, β-carotene bleaching and ion chelating assays were carried to assess the antioxidant activity, the Ellman method were used to determine the inhibition of acetylcholinesterase. Essential oil yields and compositions varied among species. The highest yield of oils (1.8%) recorded for M. pulegium. 27 compounds were identified with the predominance of oxygenated monoterpenes such as menthofurane (73.38%), rotundifolone (65.99%), pulegone (59.12%), α menthol (49.89%), menthone (20.84%), neomenthol (20.76%), 1.8-cineole (18.16%). M. aquatica and M. arvensis exhibited the strongest DPPH radical scavenging activity (IC50=0.69±0.06mg/ml and 0.76±0.20mg/ml, respectively) and the highest capacity to prevent β-carotene bleaching (IC50=0.16±0.02mg/ml and 0.22±0.01mg/ml, respectively). The uppermost ferrous ion chelating activity was observed for M. aquatica, M. arvensis and M. villosa (1.72<IC50<1.73mg/ml). Whereas essential oil of M. arvensis was found to be the most efficient (IC50=27.5μg/ml) against acetylcholinesterase. Consequently, essential oils of Mentha species could be exploited for their pharmacological application in order to prevent induced diseases relied to oxidative stress. •Algerian wild Mentha species (M. aquatica, M. arvensis, M. x piperita, M. pulegium, M. rotundifolia and M. x villosa) were reported, for the first time, in Algeria•Qualitative and quantitative variations were recorded for the essential oil components between the studied species.•All mint essential oils exhibited a noticeable antioxidant activity as determined by the three methods DPPH, β-carotene bleaching and ion chelating assays.•All tested oils possessed the ability to inhibit acetylcholinesterase with differences between the six species.