Prognostic Value of Cyclin D1 and CD44 Expression in Gastric Adenocarcinoma

• Published in: Journal of gastrointestinal cancer Vol. 50; no. 3; pp. 370 - 379
• Main Authors: Ibrahim, Hanaa M., AbdElbary, Abeer M., Mohamed, Salem Y., Elwan, Amira, Abdelhamid, Mohamed I., Ibrahim, Amr
• Format: Journal Article
• Language: English
• Published: New York Springer US 15.09.2019
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adult; Biomarkers, Tumor - metabolism; Cancer Research; Case-Control Studies; Cyclin D1 - metabolism; Female; Follow-Up Studies; Gastroenterology; Humans; Hyaluronan Receptors - metabolism; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Oncology; Original Research; Prognosis; Radiotherapy; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Survival Rate; Gastric carcinoma; Cancer stem cells; Cyclin D1; CD44
• ISSN: 1941-6628; 1941-6636
• DOI: 10.1007/s12029-018-0079-2

Background Worldwide, gastric carcinoma (GC) is the 5th most common malignancies in both sexes representing 6.8% of the total fatalities and is the 3rd leading cause of cancer death representing 8.8% of total fatalities. In Egypt, GC considers the 12th leading cause of cancer death representing 2.2% of the total cancer mortality. A growing body of evidence supports that cancer stem cells (CSCs) are resistant to chemotherapy or radiation, and the cell adhesion molecule CD44 has been identified as a cell surface marker associated with cancer stem cell in several types of tumors including gastric cancer. CD44 regulates gastric stem cell proliferation by increasing cyclin D1 expression which represents an important regulatory protein in the cell cycle transition from G1 phase to S phase. This study aimed to investigate whether cyclin D1 and CD44 can be used as prognostic indicators in gastric cancer. Material and Methods Forty formalin-fixed and paraffin-embedded gastric tissues, obtained from patients who underwent endoscopic resection or surgical resection, constituted the group of our study. The immunohistochemical expression of cyclin D1 and CD44 was examined and correlated with clinical-pathological parameters and outcome of the patients. Results Overexpression of CD44 and cyclin D1 was noted (in of 55 and 50% respectively). Cyclin D1 and CD44 positive expressions in GC were positively correlated with tumor differentiation ( p  = 0.020, p  = 0.004 respectively), TNM stage ( p  < 0.001 for both), poor survival ( p  < 0.001 for both), and with increased rate of recurrence ( p  = 0.020, p  = 0.005 respectively). Conclusion CD44 and cyclin D1 were associated with poor prognosis in gastric cancer, and so, they comprise an attractive target for anticancer drug development.