Biochemical effects of Amanita muscaria extract in mice

• Published in: Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) Vol. 24; no. 5; pp. 459 - 464_1
• Main Authors: Yamaura, Y, Komiyama, S. (Nagano-ken. Research Inst. for Health and Pollution (Japan)), Fukuhara, M, Takabatake, E, Hashimoto, T
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society for Food Hygiene and Safety 1983
• Subjects: Amanita muscaria; biochemical effect; blood glucose; CHAMPIGNON TOXIQUE; CHOLINESTERASE; COLINESTERASA; EXTRACTOS; EXTRACTS; EXTRAIT; GLICOGENO; GLUCOSA; GLUCOSE; GLYCOGEN; GLYCOGENE; HONGOS VENENOSOS; liver glycogen; POISONOUS FUNGI; poisonous mushroom; serum cholinesterase; TOXICIDAD; TOXICITE; TOXICITY; UREA; urea nitrogen; UREE
• ISSN: 0015-6426; 1882-1006
• DOI: 10.3358/shokueishi.24.459

The biochemical effects of mushroom extracts were studied in order to classify poisonous mushrooms in terms of their biochemical effects; this would provide useful information for clinical treatment. The species of mushrooms studied were Amanita muscaria, Amanita pantherina and Amanita rubrovolvata, which are known to cause nervous system disorder in man. After intraperitoneal injection of aqueous extract of A. muscaria into male mice, biochemical changes in the serum and liver were noted within 3 hours, but the values returned to normal within 6 hours after the injection. The activity of serum cholinesterase was decreased moderately at 30 minutes after the injection. The liver glycogen was decreased at 1 hour after the injection. The blood glucose level was increased at 1 hour and decreased at 3 hours after the injection. The blood urea nitrogen was decreased significantly, but serum transaminase activities were unaffected. Among the poisonous mushrooms examined, A. rubrovolvata was the most potent.