IUBMB focused meeting/FEBS workshop: Crosstalk between nucleus and mitochondria in human disease (CrossMitoNus)

• Published in: IUBMB life Vol. 73; no. 3; p. 489
• Main Authors: Díaz-Moreno, Irene, De la Rosa, Miguel A
• Format: Journal Article
• Language: English
• Published: England 01.03.2021
• Subjects: Calcium - metabolism; Cell Nucleus - metabolism; Congresses as Topic; DNA, Mitochondrial; Electron Transport Complex IV - metabolism; Friedreich Ataxia - metabolism; Humans; Iron - metabolism; Mitochondria - genetics; Mitochondria - metabolism; Mitochondrial Diseases - metabolism; Mitochondrial Diseases - pathology; Neoplasms - metabolism; Neoplasms - pathology; Spectroscopy, Near-Infrared; Stroke - metabolism; Stroke - pathology; Tumor Suppressor Protein p53 - metabolism; Voltage-Dependent Anion Channel 1 - metabolism; nucleus; IUBMB focused meeting; crosstalk; FEBS workshop; mitochondria; cell network
• ISSN: 1521-6551
• DOI: 10.1002/iub.2459

The IUBMB Focused Meeting/FEBS Workshop titled 'Crosstalk between Nucleus and Mitochondria in Human Disease'(CrossMitoNus) will take place on September 7-10, 2021 in Seville (Spain), with the support of both the International Union of Biochemistry and Molecular Biology (IUBMB) and the Federation of European Biochemical Societies (FEBS). Mitochondria are key organelles that act as a hub for vital metabolic processes, for example, energy transduction by oxidative phosphorylation, intermediary metabolism, redox signaling, calcium and iron homeostasis, heme and steroid biosynthesis, metal homeostasis, programmed cell death, and innate immunity. Consequently, a wide assortment of diseases-including neurodegenerative disorders, diabetes, cancer, rare syndromes, and many others-relate to mitochondrial dysfunction. The high relevance of mitochondria in metabolism centers on the core of cell signaling pathways, including those involved in cell-fate decisions. Critical metabolites synthesized in mitochondria are, for instance, key modulators of the sirtuin, AMPK, mTOR, and Hypoxia-inducible Factor 1A pathways. Mitochondria are indeed the major source of reactive oxygen species, which in turn mediate several regulatory routes. Interestingly, multiple nuclear-encoded factors control essential processes in mitochondrial dynamics, namely fusion (for instance, OPA1), fission (DNM1L), transport (RHOT1), and mitophagy (PINK1). The release of mitochondrial factors like cytochrome c to the cytoplasm is indeed key for the rapid onset of the intrinsic apoptotic pathway. The CrossMitoNus meeting aims to join efforts from diverse disciplines to unveil the mitochondrial and nuclear factors that are emerging as essential elements in mitochondria-nucleus communication. Needless to say, the mechanisms regulating mitochondrial protein trafficking into and out of the nucleus and the role of these proteins in the nucleus remain to be elucidated.